A cell surface protein called PD-L1 cloaks cancerous tumors from the immune system. It is estimated that approximately 40% of all malignant mesothelioma patients overexpress the PD-L1 protein – meaning that the tumor is being hidden from the immune system. Australian researchers have published a study in the Journal of Thoracic Oncology which reports that the PD-L1 protein can be deactivated from the inside.
These finding are critical because overexpression of the tumor hiding protein is highly correlated with negative treatment outcomes and shorter survival times. Too much PD-L1 leads to a higher probability of a biphasic or sarcomatoid subtype diagnosis which leads to shorter survival. The average survival time when there is no overexpression of the protein is 9.2 months, more than double the 4 month average survival time of a mesothelioma patient with overexpressed PD-L1. Author of the study,
The Paul Law Firm advocates for victims of asbestos-related diseases. If you or a loved one is suffering from mesothelioma, call the Paul Law Firm. With over 2.5 billion dollars collected for victims of asbestos exposure, we have the knowledge and the experience to fight for you. We also understand that fighting doesn’t just happen in the courtroom. It also happens in a lab where we are fighting for a cure. Check out the Mesothelioma Research Foundation of America here.
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